| Title | T wave alternans extracted from 30-minute short resting Holter ECG recordings predicts mortality in heart failure. | ||
| Author | Arsenos, Petros; Gatzoulis, Konstantinos A; Dilaveris, Polychronis; Sideris, Skevos; Tousoulis, Dimitrios | ||
| Journal | J Electrocardiol | Publication Year/Month | 2018-Jul-Aug |
| PMID | 29996995 | PMCID | -N/A- |
| Affiliation + expend | 1.First Department of Cardiology and Electrophysiology Laboratory, Hippokration General Hospital, National and Kapodistrian, University of Athens School of Medicine, Athens, Greece; Arsenos Heart and Biosignals Lab., Avlonas, Attica, Greece. Electronic address: arspetr@otenet.gr. | ||
BACKGROUND: We extracted T Wave Alternans (TWA) from a 30鈥痬inute Short Resting Holter ECG (SRH ECG) in the supine position, as a Total Mortality (TM) predictor in Heart Failure (HF). METHODS: Signals from 146 HF patients (LVEF鈥?鈥?3鈥?/-鈥?0%), were analyzed with Modified Moving Average method. After 42.1鈥痬onths, 26 patients died. RESULTS: (Deceased vs Living group): TWA:31鈥?/-鈥?8鈥痬uV vs 25鈥?/-鈥?3鈥痬uV(p鈥?鈥?.05), LVEF:32鈥?/-鈥?0% vs 34鈥?/-鈥?% (p鈥?鈥?.5), Heart Rate:73鈥?/-鈥?1鈥痓pm vs 69鈥?/-鈥?2鈥痓pm (p鈥?鈥?.2), SDNN/HRV:45鈥?/-鈥?2鈥痬s vs 41鈥?/-鈥?9鈥痬s (p鈥?鈥?.4), QRS:123鈥?/-鈥?6鈥痬s vs 119鈥?/-鈥?9鈥痬s (p鈥?鈥?.5).Cox regression model adjusted for TWA, LVEF and QRS, revealed that the TWA was an independent TM predictor (H.R.: 1.022, 95% C.I.: 0.999-1.046, p鈥?鈥?.05).The TWA鈥?/=鈥?2鈥痬uV demonstrated HR: 2.521, (95% C.I.: 0.982-6.472, p鈥?鈥?.05). CONCLUSIONS: In severely affected HF patients, TWA from a SRH ECG may be present even during slow resting heart rates and proved to be an important and independent TM predictor. The SRH ECG recording is an efficient and fast method for mortality risk evaluation in HF patients.