| Title | Enterovirus Transmission by Secretory Autophagy. | ||
| Author | Mutsafi, Yael; Altan-Bonnet, Nihal | ||
| Journal | Viruses | Publication Year/Month | 2018-Mar |
| PMID | 29558400 | PMCID | PMC5869532 |
| Affiliation + expend | 1.Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. yael.mutsafibenhalevy@nih.gov. | ||
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.