| Title | Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children With and Without an Acute Wheezing Exacerbation. | ||
| Author | Lethbridge, Robert; Prastanti, Franciska; Robertson, Cassandra; Oo, Stephen; Khoo, Siew-Kim; Le Souef, Peter N; Laing, Ingrid A | ||
| Journal | Viral Immunol | Publication Year/Month | 2018-May |
| PMID | 29446705 | PMCID | -N/A- |
| Affiliation | 1.School of Paediatrics and Child Health, University of Western Australia , Perth, Australia . | ||
To assess if the difference in species-specific immune response to RV-C correlates with a higher frequency of reinfection, shorter time to reinfection, or different symptom severity than infections with RV-A or RV-B. Forty-three patients were enrolled of which 34 were successfully tracked longitudinally over 3 months, with nasal swabs and symptom questionnaires provided every 2 weeks to identify rhinovirus (RV) strains and the concurrent symptomatology. No difference was found in the time to reinfection with an RV species between RV-C and RV-A or RV-B (p = 0.866). There was a trend toward more rapid reinfection with the same species in RV-C than RV-A (55.1 days vs. 67.9 days), but this failed to reach statistical significance (p = 0.105). RV infections were generally associated with only minor symptoms, with rhinorrhea being the only significantly associated symptom (p = 0.01). RV-C was shown to have higher levels of lethargy and wheeze than other RV species. Time to reinfection with subsequent RV is not influenced by the species of the preceding RV.