| Title | [Age-Related Changes of Heart Rate Variability at Various Insulin Sensitivity and Telomere Length]. | ||
| Author | Boytsov, A S; Tkachyeva, N O; Streltsova, I L; Dudinskaya, N E; Akasheva, U D; Plokhova, V E; Strazhesko, D I | ||
| Journal | Kardiologiia | Publication Year/Month | 2017-Jul |
| PMID | 29041881 | PMCID | -N/A- |
| Affiliation + expend | 1.State Budgetary Institution of Health Care "National Research Center for Preventive Medicine" of the Ministry of Health of the Russian Federation. | ||
AIM: To study relationship between age-associated changes of heart rate variability (HRV), telomere length (TL), and lowering of insulin sensitivity (IS). MATERIAL AND METHODS: We included in this study 229 individuals aged 23鈥?1 years without clinical manifestations of cardiovascular and other somatic diseases. In all participants, we analyzed HRV parameters obtained at 24-hour ECG monitoring (24-h ECG) and 5 minutes ECG recordings in the supine and standing positions. Leukocyte TL was estimated on genomic DNA using real time polymerase chain reaction. Insulin sensitivity was characterized by calculation of capital EN, Cyrilliccapital O, Cyrilliccapital EM, Cyrilliccapital A, Cyrillic-IR and Gutt\'s insulin sensitivity index (ISI). RESULTS: Elderly people with short telomeres (.