| Title |
Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
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| Author |
Nolte, Ilja M; Munoz, M Loretto; Tragante, Vinicius; Amare, Azmeraw T; Jansen, Rick; Vaez, Ahmad; von der Heyde, Benedikt; Avery, Christy L; Bis, Joshua C; Dierckx, Bram; van Dongen, Jenny; Gogarten, Stephanie M; Goyette, Philippe; Hernesniemi, Jussi; Huikari, Ville; Hwang, Shih-Jen; Jaju, Deepali; Kerr, Kathleen F; Kluttig, Alexander; Krijthe, Bouwe P; Kumar, Jitender; van der Laan, Sander W; Lyytikainen, Leo-Pekka; Maihofer, Adam X; Minassian, Arpi; van der Most, Peter J; Muller-Nurasyid, Martina; Nivard, Michel; Salvi, Erika; Stewart, James D; Thayer, Julian F; Verweij, Niek; Wong, Andrew; Zabaneh, Delilah; Zafarmand, Mohammad H; Abdellaoui, Abdel; Albarwani, Sulayma; Albert, Christine; Alonso, Alvaro; Ashar, Foram; Auvinen, Juha; Axelsson, Tomas; Baker, Dewleen G; de Bakker, Paul I W; Barcella, Matteo; Bayoumi, Riad; Bieringa, Rob J; Boomsma, Dorret; Boucher, Gabrielle; Britton, Annie R; Christophersen, Ingrid; Dietrich, Andrea; Ehret, George B; Ellinor, Patrick T; Eskola, Markku; Felix, Janine F; Floras, John S; Franco, Oscar H; Friberg, Peter; Gademan, Maaike G J; Geyer, Mark A; Giedraitis, Vilmantas; Hartman, Catharina A; Hemerich, Daiane; Hofman, Albert; Hottenga, Jouke-Jan; Huikuri, Heikki; Hutri-Kahonen, Nina; Jouven, Xavier; Junttila, Juhani; Juonala, Markus; Kiviniemi, Antti M; Kors, Jan A; Kumari, Meena; Kuznetsova, Tatiana; Laurie, Cathy C; Lefrandt, Joop D; Li, Yong; Li, Yun; Liao, Duanping; Limacher, Marian C; Lin, Henry J; Lindgren, Cecilia M; Lubitz, Steven A; Mahajan, Anubha; McKnight, Barbara; Zu Schwabedissen, Henriette Meyer; Milaneschi, Yuri; Mononen, Nina; Morris, Andrew P; Nalls, Mike A; Navis, Gerjan; Neijts, Melanie; Nikus, Kjell; North, Kari E; O'Connor, Daniel T; Ormel, Johan; Perz, Siegfried; Peters, Annette; Psaty, Bruce M; Raitakari, Olli T; Risbrough, Victoria B; Sinner, Moritz F; Siscovick, David; Smit, Johannes H; Smith, Nicholas L; Soliman, Elsayed Z; Sotoodehnia, Nona; Staessen, Jan A; Stein, Phyllis K; Stilp, Adrienne M; Stolarz-Skrzypek, Katarzyna; Strauch, Konstantin; Sundstrom, Johan; Swenne, Cees A; Syvanen, Ann-Christine; Tardif, Jean-Claude; Taylor, Kent D; Teumer, Alexander; Thornton, Timothy A; Tinker, Lesley E; Uitterlinden, Andre G; van Setten, Jessica; Voss, Andreas; Waldenberger, Melanie; Wilhelmsen, Kirk C; Willemsen, Gonneke; Wong, Quenna; Zhang, Zhu-Ming; Zonderman, Alan B; Cusi, Daniele; Evans, Michele K; Greiser, Halina K; van der Harst, Pim; Hassan, Mohammad; Ingelsson, Erik; Jarvelin, Marjo-Riitta; Kaab, Stefan; Kahonen, Mika; Kivimaki, Mika; Kooperberg, Charles; Kuh, Diana; Lehtimaki, Terho; Lind, Lars; Nievergelt, Caroline M; O'Donnell, Chris J; Oldehinkel, Albertine J; Penninx, Brenda; Reiner, Alexander P; Riese, Harriette; van Roon, Arie M; Rioux, John D; Rotter, Jerome I; Sofer, Tamar; Stricker, Bruno H; Tiemeier, Henning; Vrijkotte, Tanja G M; Asselbergs, Folkert W; Brundel, Bianca J J M; Heckbert, Susan R; Whitsel, Eric A; den Hoed, Marcel; Snieder, Harold; de Geus, Eco J C
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| Journal
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Nat Commun
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Publication Year/Month |
2017-Jun
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| PMID |
28613276
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PMCID
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PMC5474732
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| Affiliation
+ expend
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1.Department of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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2.Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
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3.Department of Epidemiology, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia.
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4.College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar 6000, Ethiopia.
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5.Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
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6.School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
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7.Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
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8.Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden.
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9.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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10.Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
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11.Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
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12.The Generation R Study Group, Erasmus MC, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
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13.Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
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14.Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
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15.Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
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16.Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
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17.Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
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18.Department of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
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19.Center for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
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20.Framingham Heart Study, Framingham, Massachusetts 01702, USA.
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21.Population Sciences Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
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22.Department of Clinical Physiology, Sultan Qaboos University Hospital, Muscat-Al Khoudh 123, Sultanate of Oman.
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23.Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06097, Germany.
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24.Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
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25.Laboratory of Experimental Cardiology, Department of Heart and Lung, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
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26.Department of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
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27.Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.
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28.Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg 85764, Germany.
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29.Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
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30.DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany.
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31.EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands.
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32.Department of Health Sciences, University of Milano, Milano 20122, Italy.
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33.Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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34.Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, Ohio 43210, USA.
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35.Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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36.MRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.
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37.Institute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
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38.University College London Genetics Institute, University College London, London WC1E 6BT, UK.
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39.Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
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40.Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
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41.Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman.
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42.Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
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43.Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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44.McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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45.Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland.
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46.Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden.
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47.Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
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48.Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
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49.College of Medicine, Mohammed Bin Rashid University, PO Box 505055, Dubai Healthcare City, United Arab Emirates.
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50.Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
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51.Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
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52.Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.
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53.Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, Rud 1346, Norway.
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54.Department of Child- and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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55.Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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56.Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
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57.Cardiac Arrhythmia Service &Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
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58.Department of Cardiology, University of Tampere School of Medicine, Tampere 33014, Finland.
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59.University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada M5S.
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60.Toronto General Research Institute, University Health Network, Toronto, Canada.
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61.Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
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62.Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 75237, Sweden.
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63.Interdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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64.CAPES Foundation, Ministry of Education of Brazil, Brasilia DF 70040-020, Brazil.
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65.Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
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66.Department of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
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67.Department of Pediatrics, University of Tampere School of Medicine, Tampere 33014, Finland.
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68.INSERM U970, Paris Descartes University, Paris 75006, France.
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69.Department of Medicine, University of Turku, Turku 20520, Finland.
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70.Division of Medicine, Turku University Hospital, Turku 20521, Finland.
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71.Department of Medical Informatics, Erasmus Medical Center, Rotterdam 3015 CE, The Netherlands.
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72.ISER, Essex University, Colchester, Essex CO4 3SQ, UK.
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73.Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium.
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74.Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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75.Division of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany.
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76.Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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77.Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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78.Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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79.Division of Epidemiology, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
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80.Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32611, USA.
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81.Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
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82.Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90502, USA.
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83.Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.
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84.Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
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85.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
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86.Biopharmacy, Department Pharmaceutical Sciences, University of Basel, Basel CH-4056, Switzerland.
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87.Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
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88.Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
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89.Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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90.Department of Cardiology, University of Tampere, School of Medicine, Tampere 33014, Finland.
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91.Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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92.Department of Medicine, University of California, San Diego, San Diego, California 92093, USA.
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93.Institute of Epidemiology II, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg 85764, Germany.
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94.German Center for Diabetes Research, Neuherberg 85764, Germany.
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95.Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington 98195, USA.
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96.Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.
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97.Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
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98.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
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99.The New York Academy of Medicine, New York, New York 10029, USA.
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100.Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
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101.Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, Washington 98108, USA.
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102.Epidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
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103.Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98101, USA.
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104.Heart Rate Variability Lab, Washington University School of Medicine, St Louis, Missouri 63108, USA.
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105.First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Cracow 31-008, Poland.
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106.Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universitat, Munich 81377, Germany.
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107.Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
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108.Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
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109.Universite de Montreal, Montreal, Quebec, Canada H3T IJ4.
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110.Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA.
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111.Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
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112.Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CE, The Netherlands.
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113.Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden 2300 RC, The Netherlands.
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114.Institute of Innovative Health Technologies-IGHT Jena Ernst-Abbe-Hochschule Jena, Jena 07745, Germany.
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115.Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg 85764, Germany.
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116.Departments of Genetics and Neurology University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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117.The Renaissance Computing Institute, Chapel Hill, North Carolina 27599, USA.
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118.Department of Epidemiology &Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
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119.Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
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120.Institute of Biomedical Technologies, CNR-Italian National Research Council, Milan 20090, Italy.
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121.KOS Genetic SRL, Bresso (Milano) 20091, Italy.
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122.German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg 69210, Germany.
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123.Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
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124.Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary's campus, Imperial College London, London W2 1PG, UK.
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125.Biocenter Oulu University of Oulu, Oulu 90014, Finland.
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126.Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
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127.Department of Clinical Physiology, University of Tampere, School of Medicine, Tampere 33014, Finland.
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128.Cardiology Section, Boston Veteran's Administration Healthcare, Boston, Maryland 02132, USA.
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129.Inspectorate for Health Care, The Hague 2511 VX, The Netherlands.
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130.Institute of Cardiovascular Science, University College London, 222 Euston Road, London NW1 2DA, UK.
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131.Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht 3501 DG, The Netherlands.
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132.Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1118, Amsterdam 1081 HV, The Netherlands.
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133.Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
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