| Title | Mechanism of action of the antiviral compound MDL 20,610. | ||
| Author | Kenny, M T; Torney, H L; Dulworth, J K | ||
| Journal | Antiviral Res | Publication Year/Month | 1988-Jul |
| PMID | 2849377 | PMCID | PMC7133839 |
| Affiliation | 1.Department of Pharmacology, Merrell Dow Research Institute, Indianapolis, Indiana 46268-0470. | ||
The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound\'s effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56 degrees C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.