| Title | Interacting motif networks located in hotspots associated with RNA release are conserved in Enterovirus capsids. | ||
| Author | Ross, Caroline; Knox, Caroline; Tastan Bishop, Ozlem | ||
| Journal | FEBS Lett | Publication Year/Month | 2017-Jun |
| PMID | 28471477 | PMCID | -N/A- |
| Affiliation | 1.Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa. | ||
Enteroviruses are responsible for a multitude of human diseases. Expansion of the virus capsid is associated with a cascade of conformational changes that allow the subsequent release of RNA. For the first time, this study presents a comprehensive bioinformatic screen for the prediction of interacting motifs within intraprotomer interfaces and across respective interfaces surrounding the fivefold and twofold axes. The results identify a network of conserved motif residues involved in interactions in enteroviruses that may be critical to capsid stabilisation, providing guidelines towards developing antivirals that interfere with viral expansion during RNA release.