| Title | Serologic characteristics of a human rotavirus isolate, AU-1, which has a "long" RNA pattern and subgroup I specificity. | ||
| Author | Kitaoka, S; Nakagomi, T; Fukuhara, N; Hoshino, Y; Suzuki, H; Nakagomi, O; Kapikian, A Z; Ebina, T; Konno, T; Ishida, N | ||
| Journal | J Med Virol | Publication Year/Month | 1987-Dec |
| PMID | 2826677 | PMCID | -N/A- |
| Affiliation | 1.Department of Pediatrics, Tohoku University, Sendai, Japan. | ||
An unusual human rotavirus (HRV) isolate, designated AU-1, has a "long" RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU-1 strain was demonstrated using erythrocytes of 1-day-old chicken. Neutralization assays revealed that the AU-1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU-1 gene neutralized the AU-1 strain to a significantly higher titer than the MO strain.