Title A biological perspective on differences and similarities between burnout and depression.
Author Orosz, Ariane; Federspiel, Andrea; Haisch, Sarie; Seeher, Christian; Dierks, Thomas; Cattapan, Katja
Journal Neurosci Biobehav Rev Publication Year/Month 2017-Feb
PMID 27993607 PMCID -N/A-
Affiliation + expend 1.Sanatorium Kilchberg, Centre for Stress Related Illnesses, Alte Landstrasse 70, 8802, Kilchberg, Switzerland; University Hospital of Psychiatry and Psychotherapy, Translational Research Center, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: ariane.orosz@sanatorium-kilchberg.ch.

To compare and contrast burnout and depression is not only a conceptual issue, but may deliver important directions for treatment approaches and stabilize the awareness of disease which is essential for affected individuals. Because of the symptomatic overlap, it is a subject of multidimensional research and discussion to find specific signatures to differentiate between the two phenomena or to present evidence that they are different aspects of the same disorder. Both pathologies are regarded as stress-related disorders. Therefore, in this review burnout and depression are discussed on the basis of biological parameters, mainly heart rate variability (HRV) and brain-derived neurotrophic factor (BDNF), which are crucial to the stress response system. It emerges that instead of finding one specific discriminating marker, future research should rather concentrate on elaborating indices for burnout and depression which integrate combinations of parameters found in genetics, neurobiology, physiology and environment.

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