| Title | Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial. | ||
| Author | Narkiewicz, Krzysztof; Ratcliffe, Laura E K; Hart, Emma C; Briant, Linford J B; Chrostowska, Marzena; Wolf, Jacek; Szyndler, Anna; Hering, Dagmara; Abdala, Ana P; Manghat, Nathan; Burchell, Amy E; Durant, Claire; Lobo, Melvin D; Sobotka, Paul A; Patel, Nikunj K; Leiter, James C; Engelman, Zoar J; Nightingale, Angus K; Paton, Julian F R | ||
| Journal | JACC Basic Transl Sci | Publication Year/Month | 2016-Aug |
| PMID | 27766316 | PMCID | PMC5063532 |
| Affiliation + expend | 1.Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland. | ||
Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions in ambulatory blood pressure coinciding with decreases in sympathetic activity. The carotid body may be a novel target for treating an identifiable subpopulation of humans with hypertension.