| Title | EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn. | ||
| Author | Vazquez-Perez, Joel A; Ramirez-Gonzalez, Jose E; Moreno-Valencia, Yazmin; Hernandez-Hernandez, Victor A; Romero-Espinoza, Jose A I; Castillejos-Lopez, Manuel; Hernandez, Andres; Perez-Padilla, Rogelio; Oropeza-Lopez, Lizbeth E; Escobar-Escamilla, Noe; Gonzalez-Villa, Maribel; Alejandre-Garcia, Alejandro; Regalado-Pineda, Justino; Santillan-Doherty, Patricio; Lopez-Martinez, Irma; Diaz-Quinonez, Alberto; Salas-Hernandez, Jorge | ||
| Journal | Influenza Other Respir Viruses | Publication Year/Month | 2016-May |
| PMID | 26935868 | PMCID | PMC4814865 |
| Affiliation + expend | 1.Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico. | ||
BACKGROUND: Human enterovirus D68 (EV-D68) recently caused an increase in mild-to-severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed. OBJECTIVES: The purposes of this report were to describe the clinical findings of an outbreak of EV-D68 infection in Mexico City and identify the genetic relationship with previously reported strains. PATIENTS/METHODS: Between September and December 2014, 126 nasopharyngeal samples (NPS) of hospitalized children <15 years of age with ARI were tested for the presence of respiratory viruses using a multiplex RT-qPCR and EV-D68-specific RT-qPCR. Clinical, epidemiological, and demographic data were collected and associated with symptomatology and viral infections. Phylogenetic analyses were performed using VP1 region. RESULTS: Enterovirus/rhinovirus infection was detected in 40 patients (31.7%), of which 24 patients were EV-D68-positive. EV-D68 infection prevailed over September and October 2014 and was associated with neutrophilia and lymphopenia, and patients were more likely to develop hypoxemia. Phylogenetic analyses showed that Mexican EV-D68 belongs to the new B1 clade. CONCLUSIONS: This is the first EV-D68 outbreak described in Mexico and occurred few weeks after the United States reported similar infections. Although EV-D68 belongs to new B1 clade, no neurological affection was observed.