Title Rhinovirus-induced asthma exacerbations and risk populations.
Author Coleman, Laura; Laing, Ingrid A; Bosco, Anthony
Journal Curr Opin Allergy Clin Immunol Publication Year/Month 2016-Apr
PMID 26836624 PMCID -N/A-
Affiliation 1.aTelethon Kids Institute, West Perth bSchool of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.

PURPOSE OF REVIEW: This article discusses recent findings into the mechanisms that determine how viruses trigger asthma exacerbations. RECENT FINDINGS: Substantial progress has been made in our understanding of the pathogenesis of virus-induced asthma exacerbations. This includes new insights into the role of bacteria, the regulation of interferon responses, and the discovery of innate immune pathways that link viral infections with allergic inflammation. Progress has also been made in elucidating the genetic risk factors for asthma exacerbations, most notably the contribution of the ORMDL3/GSDMB locus on 17q, the mechanisms underlying the farming effect, and the discovery that CDHR3 binds to rhinovirus species C. SUMMARY: Asthma exacerbations are heterogeneous conditions that involve the complex interplay between environmental exposures and innate and adaptive immune function in genetically predisposed individuals. Recent insights into the interrelationships between these factors provide new opportunities for therapeutic intervention.

  • Copyright © 2023
    National Institute of Pathogen Biology, CAMS & PUMC, Bejing, China
    All rights reserved.