| Title | Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0-59 Months. | ||
| Author | Nitsch-Osuch, A; Kuchar, E; Topczewska-Cabanek, A; Wardyn, K; Zycinska, K; Brydak, L | ||
| Journal | Adv Exp Med Biol | Publication Year/Month | 2016 |
| PMID | 26801151 | PMCID | PMC7119935 |
| Affiliation + expend | 1.Department of Family Medicine, Warsaw Medical University, 1A Banacha St., 02-097, Warsaw, Poland. anitsch@wum.edu.pl. | ||
Clinical data available on coinfections are contradictory concerning both the number of viruses involved and the severity of the condition. A total of 114 patients aged 0-59 months with symptoms of respiratory tract infection were enrolled into the study. Nasal and pharyngeal swabs were tested using the PCR method for the following 12 viruses: influenza A, influenza B, respiratory syncytial virus A (RSV A), respiratory syncytial virus B (RSV B), adenovirus, metapneumovirus, coronavirus 229E/NL63 (hCoV229), coronavirus OC43 (hCoVOC43), parainfluenza virus 1 (PIV-1), parainfluenza virus 2 (PIV-2), parainfluenza virus 3 (PIV-3), and rhinovirus A/B. Coinfections were detected in nine (8 %) patients. Five of the coinfections were related to influenza A (H3N2) virus associated with the following other, single or combined, respiratory viruses: influenza B in one case, hCoV229 in two cases, hCoV229, RSV A, and PIV-2 in one case, and PIV-1, PIV-2, RSV A, RSV B, and adenovirus in one case. The other four coinfections were caused by: adenovirus and hCoVOC43, adenovirus, and rhinovirus, RSV A and PIV-1, influenza B, and RSV B. We did not observe any significant differences in the clinical course of infections caused either by a single or multiple viral factors.