Title [Analysis on xTAG RVP testing results of hospitalized patients with suspected viral pneumonia].
Author Yi, Jie; Xu, Zhipeng; Xu, Yingchun
Journal Zhonghua Yi Xue Za Zhi Publication Year/Month 2015-Sep
PMID 26711982 PMCID -N/A-
Affiliation + expend 1.Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

OBJECTIVE: To analyze the testing results of hospitalized patients with suspected viral pneumonia using xTAG Respiratory Virus Panel Array (xTAG RVP). METHODS: 133 hospitalized patients with suspected viral pneumonia from Peking Union Medical College Hospital from January 2013 to December 2014 were divided into two groups, including 42 young and middle-aged patients (17-49 years old) and 91 middle and old-aged patients (50-88 years old). The nucleic acids of sputum or bronchoalveolar lavage fluid (BALF) samples from the two group patients were screened by xTAG RVP and the results were analyzed. RESULTS: Viruses can be detected from 50 out of all 133 samples, and the positive rate was 37.6%. Among the viral positive samples, the proportion of mixed infections was 12.0%. The detection rates of Influenza A virus (FluA) and Rhinovirus (RV) were higher than others (45.0% and 16.7%). The infection rate of young and middle-aged patients was significantly higher than that of the middle and old-aged patients (73.8% vs 31.9%, P<0.001). The viral detection rates of samples from spring, summer, autumn and winter were 25.0%, 6.7%, 20.0% and 38.3%, respectively. The positive rate difference among four seasons was not significant (P=0.257). CONCLUSION: FluA and RV are dominant respiratory viruses in hospitalized patients with suspected viral pneumonia, and the infection rate of the young and middle-aged patients is higher than the middle and old-aged patients.

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