Title Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 beta in rheumatoid arthritis.
Author Kosek, Eva; Altawil, Reem; Kadetoff, Diana; Finn, Anja; Westman, Marie; Le Maitre, Erwan; Andersson, Magnus; Jensen-Urstad, Mats; Lampa, Jon
Journal J Neuroimmunol Publication Year/Month 2015-Mar
PMID 25773155 PMCID PMC4372266
Affiliation + expend 1.Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Electronic address: eva.kosek@ki.se.

The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (IL)-1beta inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1beta in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM).

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