| Title | Enterovirus replication: go with the (counter)flow. | ||
| Author | Nchoutmboube, Jules; Ford-Siltz, Lauren A; Belov, George A | ||
| Journal | Trends Microbiol | Publication Year/Month | 2015-Apr |
| PMID | 25748799 | PMCID | -N/A- |
| Affiliation + expend | 1.Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA. | ||
All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.