| Title | Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations. | ||
| Author | Jackson, David J; Glanville, Nicholas; Trujillo-Torralbo, Maria-Belen; Shamji, Betty W H; Del-Rosario, Jerico; Mallia, Patrick; Edwards, Matthew J; Walton, Ross P; Edwards, Michael R; Johnston, Sebastian L | ||
| Journal | Clin Infect Dis | Publication Year/Month | 2015-May |
| PMID | 25645216 | PMCID | -N/A- |
| Affiliation + expend | 1.Airway Disease Infection Section, National Heart and Lung Institute, Imperial College Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma Imperial College Healthcare NHS Trust, London. | ||
Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.