| Title | GBF1- and ACBD3-independent recruitment of PI4KIIIbeta to replication sites by rhinovirus 3A proteins. | ||
| Author | Dorobantu, Cristina M; Ford-Siltz, Lauren A; Sittig, Simone P; Lanke, Kjerstin H W; Belov, George A; van Kuppeveld, Frank J M; van der Schaar, Hilde M | ||
| Journal | J Virol | Publication Year/Month | 2015-Feb |
| PMID | 25410869 | PMCID | PMC4300732 |
| Affiliation + expend | 1.Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. | ||
PI4KIIIbeta recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses such as poliovirus and coxsackievirus recruit PI4KIIIbeta to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIbeta to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although HRV 3A was previously shown to interact with ACBD3, our data suggest that PI4KIIIbeta recruitment occurred independently of both GBF1 and ACBD3.