| Title | Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children. | ||
| Author | Cangiano, Giulia; Proietti, Elena; Kronig, Marie Noelle; Kieninger, Elisabeth; Sadeghi, Christine D; Gorgievski, Meri; Barbani, Maria Teresa; Midulla, Fabio; Tapparel, Caroline; Kaiser, Laurent; Alves, Marco P; Regamey, Nicolas | ||
| Journal | Pediatr Infect Dis J | Publication Year/Month | 2014-Dec |
| PMID | 25389710 | PMCID | -N/A- |
| Affiliation | 1.From the *Division of Pediatric Respiratory Medicine, University Children's Hospital, Bern, Switzerland; daggerDepartment of Pediatrics, "Sapienza" University of Rome, Rome, Italy; double daggerInstitute for Infectious Diseases, University of Bern, Bern; section signCentral Laboratory of Virology, University Hospitals of Geneva, Geneva; and paragraph signDepartment of Clinical Research, University of Bern, Bern, Switzerland. | ||
The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.