| Title | The major human rhinovirus receptor is ICAM-1. | ||
| Author | Greve, J M; Davis, G; Meyer, A M; Forte, C P; Yost, S C; Marlor, C W; Kamarck, M E; McClelland, A | ||
| Journal | Cell | Publication Year/Month | 1989-Mar |
| PMID | 2538243 | PMCID | -N/A- |
| Affiliation | 1.Molecular Therapeutics, Inc., Miles Research Center, West Haven, Connecticut 06516. | ||
The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhinovirus infection. These monoclonal antibodies recognize a 95 kd cell surface glycoprotein on human cells and on mouse transfectants expressing a rhinovirus binding phenotype. Purified 95 kd protein binds to rhinovirus in vitro. Protein sequence from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1 (ICAM-1); a cDNA clone obtained from mouse transfectants expressing the rhinovirus receptor had essentially the same sequence as ICAM-1. Thus, the major human rhinovirus receptor is ICAM-1. The gene for this receptor maps to human chromosome 19, which also contains the genes for a number of other picornavirus receptors.