Socheongryeong鈥憈ang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemokine and enzyme production in the human bronchial epithelium cell line BEAS鈥?B when induced by tumor necrosis factor鈥慳lpha and interleukin鈥?. The chemokines examined included regulated on activation of normal T鈥慶ell鈥慹xpressed鈥慳nd鈥憇ecreted (RANTES), eotaxin and eotaxin鈥?. The SCRT water extract demonstrated a dose鈥慸ependent inhibition of RANTES, eotaxin, eotaxin鈥? and matrix metalloproteinase鈥? (MMP鈥?) in BEAS鈥?B cells. The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6鈥慻ingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin鈥? as well as MMP鈥? activity regardless of their concentration in SCRT water extract. Principal component analysis and hierarchical clustering analysis revealed that the inhibitory effect of these three compounds contributed to that of SCRT water extract. In conclusion, the results of the present study indicated that the inhibitory effects of SCRT on chemokine and enzyme production in BEAS鈥?B cells was associated with three of its constituent compounds, gallic acid, 6鈥慻ingerol and methyl eugenol. This therefore suggested the potential use of these compounds as anti鈥慽nflammatory agents.