| Title | Recipients with shorter cardiopulmonary bypass time achieve improvement of parasympathetic reinnervation within 6 months after heart transplantation. | ||
| Author | Imamura, Teruhiko; Kinugawa, Koichiro; Fujino, Takeo; Inaba, Toshiro; Maki, Hisataka; Hatano, Masaru; Kinoshita, Osamu; Nawata, Kan; Kyo, Shunei; Ono, Minoru | ||
| Journal | Int Heart J | Publication Year/Month | 2014 |
| PMID | 25109945 | PMCID | -N/A- |
| Affiliation | 1.Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo. | ||
Although cross-sectional late-phase reinnervation in heart transplantation (HTx) recipients has been demonstrated by several earlier studies, early-phase successive analyses especially for parasympathetic reinnervation remain unknown. Successive heart rate variability (HRV) data calculated by the MemCalc power spectral density method were obtained from 16 non-rejection recipients 1-24 weeks after HTx. High frequency (HF) level representing parasympathetic magnitude increased significantly at 6 months after HTx (from 0.9 +/- 0.7 to 4.1 +/- 2.8 ms(2*)). Only intraoperative shorter cardiopulmonary bypass time (181 +/- 59 minutes) correlated with a higher level of HF at post-HTx 6 months among all baseline variables (r = -0.530(*)). Higher level of HF was associated with recovery of tachycardia at post-HTx 6 months (r = -0.514(*)). In conclusion, parasympathetic reinnervation emerges along with recovery of tachycardia < 6 months after HTx, which is accelerated by shorter intraoperative cardiopulmonary bypass time ((*)P < 0.05 for all).