| Title | Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. | ||
| Author | MacLeod, Angus M; Mitchell, Dale R; Palmer, Nicholas J; Van de Poel, Herve; Conrath, Katja; Andrews, Martin; Leyssen, Pieter; Neyts, Johan | ||
| Journal | ACS Med Chem Lett | Publication Year/Month | 2013-Jul |
| PMID | 24900715 | PMCID | PMC4030314 |
| Affiliation + expend | 1.Medicinal Chemistry Department, BioFocus , Chesterford Research Park, Cambridge, CB10 1XL, U.K. | ||
Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIIIbeta. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.