| Title | Phenotypic directed antibody selection. | ||
| Author | McCafferty, John | ||
| Journal | Chem Biol | Publication Year/Month | 2014-Feb |
| PMID | 24560164 | PMCID | -N/A- |
| Affiliation | 1.IONTAS Ltd., Hopkins Building, Tennis Court Road, Cambridge CB2 1QW, UK. Electronic address: jmc@iontas.co.uk. | ||
In this issue of Chemistry & Biology, Xie and colleagues describe a "phenotype directed" approach to identify antibodies that protect cells from death caused by rhinovirus infection. The cellular antibody library of 10(8) clones yielded two antibodies that prevented cell death via the same viral target: rhinovirus 3C protease.