| Title | Detection of respiratory viruses in asymptomatic children undergoing allogeneic hematopoietic cell transplantation. | ||
| Author | Srinivasan, Ashok; Flynn, Patricia; Gu, Zhengming; Hartford, Christine; Lovins, Richard; Sunkara, Anusha; Srivastava, Deo K; Leung, Wing; Hayden, Randall T | ||
| Journal | Pediatr Blood Cancer | Publication Year/Month | 2013-Jan |
| PMID | 22987475 | PMCID | PMC3502722 |
| Affiliation | 1.Department of Bone Marrow Transplantation and Cellular Therapy (BMTCT), St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ashok.srinivasan@stjude.org. | ||
Detection of respiratory viruses by molecular methods, in children without respiratory symptoms undergoing hematopoietic cell transplantation (HCT), has not been well described. A prospective study of 33 asymptomatic children detected respiratory viruses in 8 of 33 (24%) patients before HCT. Human rhinovirus (HRV) was detected in five patients, and human adenovirus (hADV) in three patients. Two additional patients shed HRV, and one shed human coronavirus (hCoV), post-HCT. Two patients had co-infections. Of the 11 asymptomatic patients where respiratory virus was detected, 3 (27%) later developed an upper respiratory tract infection, from the same virus.