Title Nighttime cardiac sympathetic hyper-activation in young primary insomniacs.
Author de Zambotti, M; Covassin, N; Sarlo, M; De Min Tona, G; Trinder, J; Stegagno, L
Journal Clin Auton Res Publication Year/Month 2013-Feb
PMID 22975984 PMCID -N/A-
Affiliation 1.Department of General Psychology, University of Padova,Padua, Italy. massimiliano.dezambotti@unipd.it.

PURPOSE: A growing literature supports the association between insomnia and cardiovascular risk. Since only few studies have provided empirical evidence of hyper-activation of the cardiovascular system in insomniacs, the aim of the present study was to analyze cardiac autonomic responses in primary insomnia. METHODS: Impedance cardiography and heart rate variability (HRV) measures were assessed in 9 insomniacs and 9 good sleepers during a night of polysomnographic recording. RESULTS: Insomniacs were found to be characterized by a constant sympathetic hyper-activation which was maintained all night, as suggested by a faster pre-ejection period (PEP) compared to good sleepers. In addition, only insomniacs showed a strong reduction in heart rate in the transition from wake to sleep. Both groups exhibited a reduction in cardiac output and sympathovagal balance, i.e., reductions in low-frequency/high-frequency ratio and increases in high-frequency normalized units of HRV, across the night. In addition, in our sample, a high physiological sympathetic activation (fast PEP) at night was found to be directly associated with low quality of sleep. CONCLUSIONS: These preliminary findings suggest that a constant cardiac sympathetic hyper-activation throughout the night is a main feature of primary insomnia. Our evidences support the association between insomnia and increased risk for cardiovascular diseases.

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