| Title | Relationship between status of plasma atrial natriuretic peptide and heart rate variability in human subjects. | ||
| Author | Kasamaki, Yuji; Izumi, Yoichi; Ozawa, Yukio; Ohta, Masakatsu; Tano, Ayako; Watanabe, Ichiro; Hirayama, Atsushi; Nakayama, Tomohiro; Kawamura, Hiroshi; Himit, Dilxat; Mahemuti, Maisumu; Sezai, Akira | ||
| Journal | Heart Vessels | Publication Year/Month | 2013-Mar |
| PMID | 22370591 | PMCID | -N/A- |
| Affiliation | 1.Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashiku, Tokyo, 173-8610, Japan. kasamaki.yuuji@nihon-u.ac.jp. | ||
A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uygur, and Kazakh) provided blood and urine samples and underwent 24-h ambulatory blood pressure monitoring and 24-h ECG recording (24-h Holter ECG). There was a positive correlation between P-ANP and HF, as well as a negative correlation between P-ANP and the LF/HF ratio, in all subjects from the 3 ethnic groups. There was no association of BP with any of the blood, urinary, and HRV parameters. Our results suggested the possibility of a relationship between P-ANP and HRV, which reflects autonomic activity. These findings are consistent with the previous report of a close relationship between ANP and cardiac parasympathetic and/or sympathetic activity.