| Title | Role of PD-L1/PD-1 in the immune response to respiratory viral infections. | ||
| Author | Zdrenghea, Mihnea Tudor; Johnston, Sebastian Lennox | ||
| Journal | Microbes Infect | Publication Year/Month | 2012-Jun |
| PMID | 22285902 | PMCID | -N/A- |
| Affiliation | 1.Oncology Institute Prof. Dr. Ion Chiricuta, Department of Hematology, and University of Medicine and Pharmacy, Cluj-Napoca, Romania. mzdrenghea@umfcluj.ro. | ||
Airway epithelial cells are the main cells infected by respiratory viruses including rhinoviruses and respiratory syncytial virus. Virus modulation of inhibitory molecule PD-L1 on epithelial cells may be important in limiting anti-viral effector CD8(+) T cell responses and, consequently, worsening acute virus-induced lung tissue damage.