Clinical-electrophysiological investigation has been performed in 30 patients with acute lacunar cerebral infarct. Patients with atrial fibrillation, severe extrasystole weren\'t included to the study. The control group includes 7 health volunteers. EKG registration within 5 minutes with time domain, frequency domain analysis have been made. Brain attack on the type of lacunar IS associates with evident HRV disturbances. Centralization of the heart rate autonomic control, caused by suprasegmental part of the vegetative nervous system hyperactivity occurs against a background relative sympaticothonia and decrease of parasympathetic nervous system. In case of right carotid stroke there is significant lowering of standard deviation of the RR intervals (p=0,024), triangular index (p<0,001), total power (p=0,016), increase of mode of the histogram distribution of RR intervals (p=0,002) and the proportion derived by the number of RR intervals, that match the value of mode (p=0,001).