| Title | Synthesis of 1,4-disubstituted mono and bis-triazolocarbo-acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine by Cu(I)-catalyzed click azide-alkyne cycloaddition. | ||
| Author | Krim, Jamal; Taourirte, Moha; Engels, Joachim W | ||
| Journal | Molecules | Publication Year/Month | 2011-Dec |
| PMID | 22202806 | PMCID | PMC6269037 |
| Affiliation | 1.Laboratoire de Chimie Bioorganique et Macromoleculaire, Faculte des Sciences et Techniques-Gueliz, 40000, Marrakech, Maroc. | ||
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the azido-pseudo-sugar 4-azidobutylacetate under solvent-free microwave conditions, followed by treatment with K(2)CO(3)/MeOH, or NH(3)/MeOH. All compounds studied in this work were screened for their antiviral activities [against human rhinovirus (HRV) and hepatitis C virus (HCV)] and antibacterial activities against a series of Gram positive and negative bacteria.