| Title | Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines. | ||
| Author | Kelley, J L; Linn, J A; Selway, J W | ||
| Journal | J Med Chem | Publication Year/Month | 1990-May |
| PMID | 2158561 | PMCID | -N/A- |
| Affiliation | 1.Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709. | ||
A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.