| Title | Predictors of long-term risk for heart failure hospitalization after acute myocardial infarction. | ||
| Author | Perkiomaki, Juha S; Hamekoski, Sari; Junttila, M Juhani; Jokinen, Vesa; Tapanainen, Jari; Huikuri, Heikki V | ||
| Journal | Ann Noninvasive Electrocardiol | Publication Year/Month | 2010-Jul |
| PMID | 20645968 | PMCID | PMC6931968 |
| Affiliation | 1.Department of Medicine, University of Oulu, Finland. juha.perkiomaki@oulu.fi. | ||
BACKGROUND: Data on the value of baseline brain natriuretic peptide (BNP) and autonomic markers in predicting heart failure (HF) hospitalization after an acute myocardial infarction (AMI) are limited. METHODS: A consecutive series of patients with AMI without a previous history of HF (n = 569) were followed up for 8 years. At baseline, the patients had a blood sample for determination of BNP, a 24-hour Holter recording for evaluating heart rate variability (HRV) and heart rate turbulence (HRT), and an assessment of baroreflex sensitivity (BRS) using phenylephrine test. RESULTS: During the follow-up, 79 (14%) patients were hospitalized due to HF. Increased baseline BNP, decreased HRV, HRT, and BRS had a significant association with HF hospitalization in univariate comparisons (P < 0.001 for all). After adjusting with all the relevant clinical parameters, BNP, HRV, and HRT still significantly predicted HF hospitalization (P < 0.001 for BNP and for the short-term scaling exponent alpha(1), P < 0.01 for turbulence slope). In the receiver operator characteristics curve analysis, the area under the curve for BNP was 0.77, for the short-term scaling exponent alpha(1) 0.69, for turbulence slope 0.71, and for BNP/standard deviation of all N-N intervals ratio 0.80. CONCLUSION: Baseline increased BNP and impaired autonomic function after AMI yield significant information on the long-term risk for HF hospitalization.