| Title | Pre-clinical safety evaluation of pyrrolidine dithiocarbamate. | ||
| Author | Chabicovsky, Monika; Prieschl-Grassauer, Eva; Seipelt, Joachim; Muster, Thomas; Szolar, Oliver H J; Hebar, Alexandra; Doblhoff-Dier, Otto | ||
| Journal | Basic Clin Pharmacol Toxicol | Publication Year/Month | 2010-Sep |
| PMID | 20406205 | PMCID | -N/A- |
| Affiliation | 1.MC Toxicology Consulting, Vienna, Austria. | ||
Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non-clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single-dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues.