| Title | Sex-based differences in the association between duration of type 2 diabetes and heart rate variability. | ||
| Author | Nolan, Robert P; Barry-Bianchi, Susan M; Mechetiuc, Adriana E; Chen, Maggie H | ||
| Journal | Diab Vasc Dis Res | Publication Year/Month | 2009-Oct |
| PMID | 20368222 | PMCID | -N/A- |
| Affiliation | 1.Behavioral Cardiology Research Unit, University Health Network, 585 University Ave., Toronto, ON M5G 2N2, Canada. rnolan@uhnres.utoronto.ca. | ||
We examined the association between heart rate variability (HRV) and duration of type 2 diabetes among 155 female and 106 male subjects: mean+/-SD for duration=49.6+/-65.6 and 57.3+/-77.1 months, respectively, p=0.38. Among males, duration of diabetes was independently and inversely associated with vagal-heart rate modulation (high frequency (HF) power, 0.15-0.40 Hz, standardised ss = -0.32, p=0.001; root mean square of successive differences between R-R intervals, ss = -0.26, p=0.006) and total R-R variability (standard deviation of normal R-R intervals, ss = -0.36, p=0.001); but not among females (p> or =0.80 for each HRV index). In contrast, HF was inversely associated with age of diabetes diagnosis (ss = -0.16, p=0.04) and 10-year absolute risk for coronary heart disease (ss = -0.16, p=0.04) among female subjects. Longitudinal research is needed to establish whether risk factors for early cardiac autonomic impairment differ among men and women with type 2 diabetes.