| Title | Effect of a polynucleotide interferon inducer of fungal origin on experimental rhinovirus infection in humans. | ||
| Author | Aoki, F Y; Reed, S E; Craig, J W; Tyrrell, D A; Lees, L J | ||
| Journal | J Infect Dis | Publication Year/Month | 1978-Jan |
| PMID | 203635 | PMCID | -N/A- |
A double-stranded RNA of fungal origin (BRL 5907) was given intranasally to volunteers. Apart from mild local irritancy of the higher dosage, the compound was well tolerated. A double-blind placebo-controlled trial of a three-day course (5 mg per day) of BRL 5907 against challenge with rhinovirus type 4 showed that treatment was associated with a delay in onset of symptoms and a reduction in shedding of virus, but the differences were not statistically significant. Low titers of interferon were found in nasal washings.