Title | Heart rate variability on 7-day Holter monitoring using a bootstrap rhythmometric procedure. | ||
Author | Goya-Esteban, Rebeca; Mora-Jimenez, Inmaculada; Rojo-Alvarez, Jose Luis; Barquero-Perez, Oscar; Pastor-Perez, Francisco J; Manzano-Fernandez, Sergio; Pascual-Figal, Domingo A; Garcia-Alberola, Arcadi | ||
Journal | IEEE Trans Biomed Eng | Publication Year/Month | 2010-Jun |
PMID | 20172786 | PMCID | -N/A- |
Affiliation | 1.Department of Signal Theory and Communications, University Rey Juan Carlos, Fuenlabrada-28943, Madrid, Spain. rebeca.goyaesteban@urjc.es. |
Heart rate variability (HRV) markers have been widely used to characterize the autonomous regulation state of the heart from 24-h Holter monitoring, but long-term evolution of HRV indexes is mostly unknown. A dataset of 7-day Holter recordings of 22 patients with congestive heart failure was studied. A rhythmometric procedure was designed to characterize the infradian, circadian, and ultradian components for each patient, as well as circadian and ultradian fluctuations. Furthermore, a bootstrap test yielded automatically the rhythmometric model for each patient. We analyzed the temporal evolution of relevant time-domain (AVNN, SDNN, and NN50), frequency-domain (LF, HF, HFn, and LF/HF), and nonlinear (alpha(1) and SampEn) HRV indexes. Circadian components were the most significant for all HRV indexes, but the infradian ones were also strongly present in NN50, HFn, LF/HF, alpha(1), and SampEn indexes. Among ultradian components that one corresponding to 12 h, was the most relevant. Long-term monitoring of HRV conveys new potentially relevant rhythmometric information, which can be analyzed by using the proposed automatic procedure.