| Title | Structure and in vitro antiviral activity of sesquiterpene glycosides from Calendula arvensis. | ||
| Author | De Tommasi, N; Pizza, C; Conti, C; Orsi, N; Stein, M L | ||
| Journal | J Nat Prod | Publication Year/Month | 1990-Jul-Aug |
| PMID | 1965654 | PMCID | -N/A- |
| Affiliation | 1.Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli, Italy. | ||
Previous research on the aerial parts of Calendula arvensis led to the isolation of the epicubebol glycoside 1 and of the sesquiterpene glycosides 2-5 based on the alloaromadendrane skeleton. A further investigation has revealed two new glycosides, 6 and 7, derived from the same sesquiterpene, the structures of which were elucidated by spectral studies. Furthermore a series of antiviral tests has been performed on glycosides 1-7 by examining their ability to interfere with rhinovirus 1B and vesicular stomatitis virus infection in vitro. Only glycoside 1 slightly reduced rhinovirus multiplication. All the compounds were able to inhibit vesicular stomatitis virus infection, 1 and 2 being the most effective.