| Title | [Lisinopril: antihypertensive activity, effects on heart rhythm variability and carbohydrate metabolism in patients with metabolic syndrome]. | ||
| Author | Shevchenko, O P; Praskurnichii, E A; Savel'eva, S A | ||
| Journal | Ter Arkh | Publication Year/Month | 2008 |
| PMID | 19105412 | PMCID | -N/A- |
AIM: To examine antihypertensive activity, heart rate variability (HRV) and carbohydrate metabolism of ACE inhibitor lisinopril in patients with metabolic syndrome (MS). MATERIAL AND METHODS: Twenty MS patients (13 females and 7 males) received lisinopril monotherapy for 12 weeks. Before the treatment and after 12 weeks of lisinopril treatment the following tests were made: office measurement of blood pressure (BP), 24-hour BP monitoring, exercise test, investigation of HRV and carbohydrate profile. RESULTS: A 12-week treatment with lisinopril had high antihypertensive efficacy, its positive action on HRV and carbohydrate metabolism manifested in reduction of postprandial glycemia and insulinemia.