| Title | Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors. | ||
| Author | Fan, Shi-Yong; Zheng, Zhi-Bing; Mi, Chun-Lai; Zhou, Xin-Bo; Yan, Hui; Gong, Ze-Hui; Li, Song | ||
| Journal | Bioorg Med Chem | Publication Year/Month | 2009-Jan |
| PMID | 19091578 | PMCID | -N/A- |
| Affiliation | 1.Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. | ||
Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.