RVdb-Rhinovirus Database

Basic information

Title	A novel group of rhinoviruses is associated with asthma hospitalizations.
Author	Miller, E Kathryn; Edwards, Kathryn M; Weinberg, Geoffrey A; Iwane, Marika K; Griffin, Marie R; Hall, Caroline B; Zhu, Yuwei; Szilagyi, Peter G; Morin, Laura-Lee; Heil, Luke H; Lu, Xiaoyan; Williams, John V
Journal	J Allergy Clin Immunol	Publication Year/Month	2009-Jan
PMID	19027147	PMCID	PMC7112283
Affiliation	1.Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-9500, USA. eva.k.miller@vanderbilt.edu.

Abstract

BACKGROUND: Although recent studies have identified new group C human rhinoviruses (HRVCs), their spectrum of pediatric disease is unknown. OBJECTIVE: We sought to determine the presentation and burden of disease caused by HRVCs among young hospitalized children. METHODS: We conducted prospective population-based surveillance in 2 US counties among children less than 5 years of age hospitalized with acute respiratory illness or fever from October 2001 through September 2003. Nasal/throat swabs were obtained and tested for HRVs, as determined by means of RT-PCR and then characterized by means of partial sequencing. RESULTS: Of 1052 children enrolled and tested during the 2-year period, 167 (16%) had HRVs detected. Of 147 samples successfully sequenced, 64 were group A HRVs, 6 were group B HRVs, and 77 were HRVCs. Children with HRVCs were significantly more likely than those with group A HRVs to have underlying high-risk conditions, such as asthma (42% vs 23%, P = .023) and to have had a discharge diagnosis of asthma (55% vs 36%, P = .022). CONCLUSIONS: Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease.

MeSH terms

Asthma/diagnosis/*epidemiology/virology

Communicable Diseases, Emerging/diagnosis/*epidemiology/genetics/virology

Picornaviridae Infections/diagnosis/*epidemiology/genetics

*Rhinovirus/genetics/isolation & purification

Acute Disease

Child, Preschool

Female

Follow-Up Studies

Hospitalization

Humans

Infant

Male

New York

Prospective Studies

Related RV Strain

StrainID	RV Species	Serotype	Length(nt)	Country	Year	Strain Name
UNS00936	Unclassified	None	435	USA	2001	RV588
UNS00937	Unclassified	None	436	USA	2003	RV1060
UNS00938	Unclassified	None	435	USA	2001	RV611
UNS00939	Unclassified	None	435	USA	2003	RV350
UNS00940	Unclassified	None	435	USA	2002	RV39
UNS00941	Unclassified	None	435	USA	2002	RV842
UNS00942	Unclassified	None	435	USA	2002	RV821
UNS00943	Unclassified	None	435	USA	2001	RV147
UNS00944	Unclassified	None	435	USA	2002	RV681
UNS00945	Unclassified	None	435	USA	2003	RV1156
UNS00946	Unclassified	None	435	USA	2003	RV460
UNS00947	Unclassified	None	435	USA	2003	RV404
UNS00948	Unclassified	None	435	USA	2003	RV403
UNS00949	Unclassified	None	435	USA	2002	RV226
UNS00950	Unclassified	None	435	USA	2002	RV218
UNS00951	Unclassified	None	435	USA	2002	RV815
UNS00952	Unclassified	None	435	USA	2002	RV827
UNS00953	Unclassified	None	435	USA	2002	RV1023
UNS00954	Unclassified	None	435	USA	2003	RV416
UNS00955	Unclassified	None	435	USA	2003	RV97
UNS00956	Unclassified	None	435	USA	2003	RV414
UNS00957	Unclassified	None	435	USA	2003	RV116
UNS00958	Unclassified	None	435	USA	2003	RV1143
UNS00959	Unclassified	None	435	USA	2003	RV100
UNS00960	Unclassified	None	435	USA	2002	RV182
UNS00961	Unclassified	None	435	USA	2001	RV168
UNS00962	Unclassified	None	435	USA	2003	RV463
UNS00963	Unclassified	None	435	USA	2001	RV152
UNS00964	Unclassified	None	435	USA	2001	RV5
UNS00965	Unclassified	None	435	USA	2003	RV1149
UNS00966	Unclassified	None	435	USA	2002	RV849
UNS00967	Unclassified	None	435	USA	2002	RV238
UNS00968	Unclassified	None	435	USA	2002	RV824
UNS00969	Unclassified	None	435	USA	2002	RV268
UNS00970	Unclassified	None	435	USA	2002	RV236
UNS00971	Unclassified	None	435	USA	2003	RV422
UNS00972	Unclassified	None	435	USA	2003	RV69
UNS00973	Unclassified	None	435	USA	2003	RV415
UNS00974	Unclassified	None	435	USA	2002	RV284
UNS00975	Unclassified	None	435	USA	2002	RV282
UNS00976	Unclassified	None	435	USA	2002	RV298
UNS00977	Unclassified	None	435	USA	2002	RV749
UNS00978	Unclassified	None	435	USA	2002	RV856
UNS00979	Unclassified	None	435	USA	2003	RV525
UNS00980	Unclassified	None	435	USA	2002	RV501
UNS00981	Unclassified	None	435	USA	2002	RV818
UNS00982	Unclassified	None	435	USA	2002	RV498
UNS00983	Unclassified	None	435	USA	2002	RV440
UNS00984	Unclassified	None	435	USA	2001	RV17
UNS00985	Unclassified	None	435	USA	2001	RV13
UNS00986	Unclassified	None	435	USA	2002	RV331
UNS00987	Unclassified	None	435	USA	2002	RV814
UNS00988	Unclassified	None	435	USA	2002	RV828
UNS00989	Unclassified	None	435	USA	2002	RV35
UNS00990	Unclassified	None	435	USA	2002	RV496
UNS00991	Unclassified	None	435	USA	2003	RV461
UNS00992	Unclassified	None	435	USA	2002	RV489
UNS00993	Unclassified	None	435	USA	2003	RV1132
UNS00994	Unclassified	None	435	USA	2002	RV777
UNS00995	Unclassified	None	435	USA	2001	RV429
UNS00996	Unclassified	None	435	USA	2002	RV305
UNS00997	Unclassified	None	435	USA	2003	RV426
UNS00998	Unclassified	None	435	USA	2003	RV537
UNS00999	Unclassified	None	435	USA	2003	RV122
UNS01000	Unclassified	None	435	USA	2001	RV543
UNS01001	Unclassified	None	435	USA	2003	RV107
UNS01002	Unclassified	None	435	USA	2003	RV389
UNS01003	Unclassified	None	420	USA	2002	RV934
UNS01004	Unclassified	None	435	USA	2001	RV148
UNS01005	Unclassified	None	435	USA	2002	RV867
UNS01006	Unclassified	None	435	USA	2001	RV538
UNS01007	Unclassified	None	435	USA	2001	RV145
UNS01008	Unclassified	None	435	USA	2002	RV512
UNS01009	Unclassified	None	435	USA	2002	RV1026
UNS01010	Unclassified	None	435	USA	2001	RV542
UNS01011	Unclassified	None	435	USA	2002	RV940
UNS01012	Unclassified	None	435	USA	2002	RV921
UNS01013	Unclassified	None	429	USA	2003	RV1250
UNS01014	Unclassified	None	429	USA	2003	RV1204
UNS01015	Unclassified	None	429	USA	2001	RV431
UNS01016	Unclassified	None	429	USA	2002	RV882
UNS01017	Unclassified	None	429	USA	2002	RV513
UNS01018	Unclassified	None	429	USA	2003	RV1164
UNS01019	Unclassified	None	429	USA	2003	RV468
UNS01020	Unclassified	None	429	USA	2003	RV402
UNS01021	Unclassified	None	429	USA	2003	RV112
UNS01022	Unclassified	None	429	USA	2003	RV1130
UNS01023	Unclassified	None	429	USA	2003	RV138
UNS01024	Unclassified	None	429	USA	2002	RV307
UNS01025	Unclassified	None	428	USA	2003	RV351
UNS01026	Unclassified	None	429	USA	2003	RV458
UNS01027	Unclassified	None	414	USA	2002	RV947
UNS01028	Unclassified	None	429	USA	2002	RV928
UNS01029	Unclassified	None	429	USA	2002	RV930
UNS01030	Unclassified	None	429	USA	2001	RV161
UNS01031	Unclassified	None	429	USA	2001	RV151
UNS01032	Unclassified	None	429	USA	2003	RV471
UNS01033	Unclassified	None	429	USA	2002	RV946
UNS01034	Unclassified	None	429	USA	2003	RV470
UNS01035	Unclassified	None	429	USA	2003	RV1221
UNS01036	Unclassified	None	429	USA	2001	RV541
UNS01037	Unclassified	None	429	USA	2001	RV554
UNS01038	Unclassified	None	429	USA	2003	RV1231
UNS01039	Unclassified	None	429	USA	2002	RV309
UNS01040	Unclassified	None	429	USA	2003	RV121
UNS01041	Unclassified	None	429	USA	2001	RV7
UNS01042	Unclassified	None	429	USA	2002	RV505
UNS01043	Unclassified	None	429	USA	2002	RV451
UNS01044	Unclassified	None	429	USA	2002	RV329
UNS01045	Unclassified	None	429	USA	2002	RV308
UNS01046	Unclassified	None	429	USA	2003	RV1131
UNS01047	Unclassified	None	429	USA	2001	RV11
UNS01048	Unclassified	None	429	USA	2002	RV1018
UNS01049	Unclassified	None	429	USA	2003	RV1051
UNS01050	Unclassified	None	429	USA	2003	RV369
UNS01051	Unclassified	None	429	USA	2003	RV1137
UNS01052	Unclassified	None	424	USA	2002	RV314
UNS01053	Unclassified	None	429	USA	2002	RV1039
UNS01054	Unclassified	None	429	USA	2001	RV585
UNS01055	Unclassified	None	429	USA	2002	RV37
UNS01056	Unclassified	None	429	USA	2002	RV507
UNS01057	Unclassified	None	429	USA	2002	RV499
UNS01058	Unclassified	None	429	USA	2002	RV212
UNS01059	Unclassified	None	429	USA	2002	RV809
UNS01060	Unclassified	None	414	USA	2002	RV866
UNS01061	Unclassified	None	429	USA	2002	RV506
UNS01062	Unclassified	None	429	USA	2002	RV320
UNS01063	Unclassified	None	429	USA	2002	RV303
UNS01064	Unclassified	None	429	USA	2002	RV862
UNS01065	Unclassified	None	429	USA	2002	RV323
UNS01066	Unclassified	None	429	USA	2002	RV317
UNS01067	Unclassified	None	429	USA	2001	RV546
UNS01068	Unclassified	None	414	USA	2002	RV912
UNS01069	Unclassified	None	429	USA	2002	RV502
UNS01070	Unclassified	None	429	USA	2002	RV817
UNS01071	Unclassified	None	429	USA	2002	RV729
UNS01072	Unclassified	None	429	USA	2002	RV262
UNS01073	Unclassified	None	429	USA	2002	RV266
UNS01074	Unclassified	None	429	USA	2003	RV459
UNS01075	Unclassified	None	429	USA	2002	RV57
UNS01076	Unclassified	None	429	USA	2003	RV396
UNS01077	Unclassified	None	429	USA	2002	RV265
UNS01078	Unclassified	None	430	USA	2003	RV405
UNS01079	Unclassified	None	429	USA	2002	RV64
UNS01080	Unclassified	None	429	USA	2002	RV1041
UNS01081	Unclassified	None	429	USA	2003	RV408
UNS01082	Unclassified	None	429	USA	2003	RV1123
UNS01083	Unclassified	None	429	USA	2003	RV1207
UNS01084	Unclassified	None	429	USA	2002	RV820
UNS01085	Unclassified	None	429	USA	2003	RV1152
UNS01086	Unclassified	None	429	USA	2003	RV1174
UNS01087	Unclassified	None	429	USA	2001	RV430
UNS01088	Unclassified	None	429	USA	2001	RV638
UNS01089	Unclassified	None	429	USA	2002	RV772
UNS01090	Unclassified	None	429	USA	2002	RV254
UNS01091	Unclassified	None	429	USA	2003	RV1066
UNS01092	Unclassified	None	429	USA	2003	RV374
UNS01093	Unclassified	None	429	USA	2002	RV66
UNS01094	Unclassified	None	429	USA	2002	RV945
UNS01095	Unclassified	None	429	USA	2003	RV106
UNS01096	Unclassified	None	414	USA	2002	RV177
UNS01097	Unclassified	None	428	USA	2003	RV1253
UNS01098	Unclassified	None	429	USA	2002	RV508
UNS01099	Unclassified	None	429	USA	2002	RV813
UNS01100	Unclassified	None	429	USA	2002	RV61

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