| Title | Synthesis and antirhinovirus activity of 8-substituted analogues of 6-(dimethylamino)-9-(4-methylbenzyl)-2-(trifluoromethyl)-9H-purine. | ||
| Author | Kelley, J L; Linn, J A; Selway, J W | ||
| Journal | J Med Chem | Publication Year/Month | 1991-Jan |
| PMID | 1846916 | PMCID | -N/A- |
| Affiliation | 1.Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709. | ||
Several 8-substituted analogues of 6-(dimethylamino) -9-(4-methylbenzyl)-2-(trifluoromethyl)-9H-purine (1) were synthesized and tested for activity against rhinovirus type 1B. Among 16 8-substituted analogues, the 8-amino (3) and 8-bromo (2) analogues were most active with IC50s of 0.36 and 1.4 microM, respectively, under conditions where 1 had an IC50 of 0.03 microM.