| Title | Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis. | ||
| Author | Scagnolari, Carolina; Midulla, Fabio; Trombetti, Simona; Pierangeli, Alessandra; Tromba, Valeria; Grossi, Rosanna; Di Marco, Paola; Dianzani, Caterina; Girardi, Enrico; Antonelli, Guido | ||
| Journal | Exp Biol Med (Maywood) | Publication Year/Month | 2007-Nov |
| PMID | 17959848 | PMCID | -N/A- |
| Affiliation | 1.Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy. | ||
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.