| Title | Enterovirus surveillance reveals proposed new serotypes and provides new insight into enterovirus 5\'-untranslated region evolution. | ||
| Author | Smura, Teemu; Blomqvist, Soile; Paananen, Anja; Vuorinen, Tytti; Sobotova, Zdenka; Bubovica, Veronika; Ivanova, Olga; Hovi, Tapani; Roivainen, Merja | ||
| Journal | J Gen Virol | Publication Year/Month | 2007-Sep |
| PMID | 17698662 | PMCID | -N/A- |
| Affiliation + expend | 1.Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland. | ||
Human enteroviruses are currently grouped into five species Human enterovirus A (HEV-A), HEV-B, HEV-C, HEV-D and Poliovirus. During surveillance for enteroviruses serologically non-typable enterovirus strains were found from acute flaccid paralysis patients and healthy individuals. In this study, we report isolates of recently described enterovirus types EV76 and EV90 of HEV-A species and characterize two new enterovirus type candidates, EV96 and EV97, to species HEV-C and HEV-B, respectively. Analysis of partial 3D regions of EV96 strains revealed sequence divergence consistent with several recombination events between EV96, other HEV-C viruses and polioviruses. Phylogenetic analysis of all available 5\'-untranslated region sequences of human entero- and rhinovirus prototype strains and 10 simian enterovirus strains suggested interspecies recombination involving this region.