| Title | Induction of autophagy does not affect human rhinovirus type 2 production. | ||
| Author | Brabec-Zaruba, Marianne; Berka, Ursula; Blaas, Dieter; Fuchs, Renate | ||
| Journal | J Virol | Publication Year/Month | 2007-Oct |
| PMID | 17670838 | PMCID | PMC2045498 |
| Affiliation | 1.Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. | ||
Induction of autophagy has been shown to be beneficial for the replication of poliovirus, a phenomenon that might also apply for other picornaviruses. We demonstrate that de novo synthesis of human rhinovirus type 2 (HRV2), an HRV of the minor receptor group, is unaffected by tamoxifen, rapamycin, and 3-methyladenine (3-MA), drugs either stimulating (tamoxifen and rapamycin) or inhibiting (3-MA) autophagic processes. Furthermore, LC3-positive vesicles (i.e., autophagosomes) are not induced upon infection. Therefore, multiplication of this particular picornavirus is not dependent on autophagy.