| Title | Human responses to two decavalent rhinovirus vaccines. | ||
| Author | Hamory, B H; Hamparian, V V; Conant, R M; Gwaltney, J M Jr | ||
| Journal | J Infect Dis | Publication Year/Month | 1975-Dec |
| PMID | 172561 | PMCID | -N/A- |
Two formalin-inactivated, decavalent rhinovirus vaccines were tested in humans for acceptability and antigenicity. Infectivity titers of the vaccine antigens were low and ranged from 10(1.5) to 10(5.5) 50% tissue culture infective doses/ml. There were minimal or no side effects to either vaccine. The first inoculation of one vaccine produced antigenic responses to 30% of the administered antigens. Limited testing for heterologous antibody responses to nonvaccine antigens showed scattered responses. These findings suggest that potent multivalent rhinovirus vaccines containing antigens selected for cross-reactivity should be tested in an attempt to develop practical control measures for rhinoviruses.