Title | Towards assessing the sympathovagal balance. | ||
Author | Lafitte, Melvyn J; Sauvageot, Orin R; Fevre-Genoulaz, Marion; Zimmermann, Marc | ||
Journal | Med Biol Eng Comput | Publication Year/Month | 2006-Aug |
PMID | 16937209 | PMCID | -N/A- |
Affiliation | 1.Cardiovascular Department, Hopital de la Tour Meyrin, Geneva, Switzerland. |
Exact assessment of the autonomic nervous system\'s (ANS) activity by means of heart rate variability (HRV) is a long-standing challenge. Although many techniques have been proposed to take up the challenge, none ever proposed a rationale for the approach behind the technique or a satisfying discrimination of the two activities which underlie the autonomic control of HRV. We here propose a new method, providing both an understanding of the discrimination\'s nature and a framework which we believe leads to a thorough assessment of the sympathovagal balance, as a trajectory between points in a well-chosen space. The methodology assumes tools from scale invariance/covariance physics. The sympathovagal balance is obtained on a beat-to-beat basis with the dynamics portrayed through a trajectory. Furthermore, universal trajectories are sought which would comprehensively describe the effect of atropine and isoproterenol injections on systems underlying the heart pace variations. Non-invasive assessment of the respective activities of the sympathetic and parasympathetic subsystems of the ANS would be possible through cardiac autonomic measurements.