| Title | Antiviral activity of constituents of Tamus communis. | ||
| Author | Aquino, R; Conti, C; De Simone, F; Orsi, N; Pizza, C; Stein, M L | ||
| Journal | J Chemother | Publication Year/Month | 1991-Oct |
| PMID | 1667189 | PMCID | -N/A- |
| Affiliation | 1.Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli, Italy. | ||
The antiviral activity of the phenanthrene derivatives 1-6, of the spyrostane triglycosides dioscin (7) and gracillin (8), of the furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), and methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus and human rhinovirus type 1B. All these products were extracted from the rizomes of Tamus communis L; compound 11 was isolated also from Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20 (22)-unsaturated furostanoside, which was also investigated for antiviral activity. The results were of some interest mainly for the phenanthrene derivatives.