| Title | Effect of ascorbic acid on rhinovirus replication in WI-38 cells. | ||
| Author | Schwerdt, P R; Schwerdt, C E | ||
| Journal | Proc Soc Exp Biol Med | Publication Year/Month | 1975-Apr |
| PMID | 165544 | PMCID | -N/A- |
Exposure of WI-38 cells to ascorbic acid plus glutathione mixtures in growth medium for 2 days prior to infection with rhinovirus serotype 20 and during virus replication suppressed multicyclic but not single-cycle growth of the virus. Multicyclic growth was suppressed over the range of multiplicity of infection (m.o.i.) of 4 times 10-minus 1 minus 4 times 10-minus 4 PFU/cell. There was some suggestion that, in the presence of ascorbic acid plus glutathione, interferon was produced at the highest m.o.i. tested but at barely detectable levels.