| Title | The effects of exercise training on myocardial adrenergic and muscarinic receptors. | ||
| Author | Barbier, Julie; Reland, Sylvia; Ville, Nathalie; Rannou-Bekono, Francoise; Wong, Sara; Carre, Francois | ||
| Journal | Clin Auton Res | Publication Year/Month | 2006-Feb |
| PMID | 16477498 | PMCID | -N/A- |
| Affiliation | 1.Laboratory of Physiology and Biomechanics of Muscular Exercise, UFR-APS, University of Rennes 2, Av. Charles Tillon, 35044 Rennes Cedex, France. julie.barbier@uhb.frt. | ||
We investigated the effects of exercise training on heart rate variability (HRV) and myocardial adrenergic and muscarinic receptors in rats. Exercise training induced a decrease in body mass while ventricular size remained unchanged, a development we considered as a relative cardiac hypertrophy. In addition, there was a reduction in the density of myocardial beta(1)-adrenergic receptors. These structural changes were associated with functional adaptations, as illustrated by the increased response of the sinus node to sympathetic blockade.