| Title | Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase. | ||
| Author | Deszcz, Luiza; Seipelt, Joachim; Vassilieva, Elena; Roetzer, Andreas; Kuechler, Ernst | ||
| Journal | FEBS Lett | Publication Year/Month | 2004-Feb |
| PMID | 14987997 | PMCID | -N/A- |
| Affiliation | 1.Department of Medical Biochemistry, Division of Biochemistry, University of Vienna, Dr. Bohr Gasse 9/3, A-1030 Vienna, Austria. | ||
Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases.